Photocytotoxicity and Magnetic Relaxivity Responses of Dual-Porous γ-Fe2O3@meso-SiO2 Microspheres
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AbstractNovel high magnetization microspheres with porous γ-Fe2O3 core and porous SiO2 shell were synthesized using a templating method, whereas the size of the magnetic core and the thickness of the porous shell can be controlled by tuning the experimental parameters. By way of an example, as-prepared γ-Fe2O3@meso-SiO2 microspheres (170 nm) display excellent water-dispersity and show photonic characteristics under externally applied a magnetic field. The magnetic property of the γ-Fe2O3 porous core enables the microspheres to be used as a contrast agent in magnetic resonance imaging with a high r2 (76.5 s–1 mM–1 Fe) relaxivity. The biocompatible composites possess a large BET surface area (222.3 m2/g), demonstrating that they can be used as a bifunctional agent for both MRI and drug carrier. Because of the high substrate loading of the magnetic, dual-porous materials, only a low dosage of the substrate will be acquired for potential practical applications. Hydrophobic zinc(II) phthalocyanine (ZnPC) photosensitizing molecules have been encapsulated into the dual-porous microspheres to form γ-Fe2O3@meso-SiO2–ZnPC microspheres. Biosafety, cellular uptake in HT29 cells, and in vitro MRI of these nanoparticles have been demonstrated. Photocytotoxicity (λ > 610 nm) of the HT29 cells uptaken with γ-Fe2O3@meso-SiO2–ZnPC microspheres has been demonstrated for 20 min illumination.
All Author(s) ListXuan SH, Lee SF, Lau JTF, Zhu XM, Wang YXJ, Wang F, Lai JMY, Sham KWY, Lo PC, Yu JC, Cheng CHK, Leung KCF
Journal nameACS Applied Materials and Interfaces
Year2012
Month4
Volume Number4
Issue Number4
PublisherAMER CHEMICAL SOC
Pages2033 - 2040
ISSN1944-8244
eISSN1944-8252
LanguagesEnglish-United Kingdom
Keywordsdrug carrier, magnetic resonance imaging, nanoparticle, photocytotoxicity, porosity
Web of Science Subject CategoriesMaterials Science; Materials Science, Multidisciplinary; MATERIALS SCIENCE, MULTIDISCIPLINARY; Nanoscience & Nanotechnology; NANOSCIENCE & NANOTECHNOLOGY; Science & Technology - Other Topics

Last updated on 2020-01-12 at 00:23