Prospective self-controlled trial of the efficacy and tolerability of a herbal syrup for young children with eczema
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摘要Objectives: Traditional Chinese medicine (TCM) is popular as an alternative medicine in children with atopic dermatitis (AD). A concoction of five herbs in a capsular preparation has been confirmed to be efficacious in improving the quality of life and sparing topical corticosteroid usage. We evaluated the clinical efficacy and tolerability of the same concoction in syrup form. Methods: This was a prospective self-controlled trial set in the pediatric dermatology clinic of a teaching hospital. Children aged 4-7 years with moderate-to-severe AD received 20 ml of TCM syrup daily. Clinical parameters and laboratory markers were measured before and at 2 weeks, 7 weeks and 12 weeks of treatment, and at 4 weeks after completion. Disease severity was evaluated by the SCORing Atopic Dermatitis (SCORAD) index and quality of life by the Children's Dermatology Life Quality Index (CDLQI). Blood was obtained for a complete blood count, total IgE, eosinophil count, and biochemical studies prior to and after 3 months of TCM usage. Results: Twenty-two patients participated in the study. There were significant improvements in the objective SCORAD, pruritus and CDLQI scores 4 weeks after study completion. There was no change in sleep score or amount of topical steroid consumption. No biochemical evidence of any adverse drug reaction was observed during the study period. The TCM syrup was generally palatable and well tolerated by the children. Adverse effects were generally mild but two patients with rash withdrew during the study. Conclusion: The palatability means that further evaluations and dosage studies of the concoction will be possible in young children.
著者Hon KL, Lo W, Cheng WKF, Leung TF, Chow CM, Lau CBS, Fok TF, Ng PC, Leung PC
期刊名稱Journal of Dermatological Treatment
出版年份2012
月份4
日期1
卷號23
期次2
出版社INFORMA HEALTHCARE
頁次116 - 121
國際標準期刊號0954-6634
電子國際標準期刊號1471-1753
語言英式英語
關鍵詞atopic dermatitis; children; traditional Chinese medicine
Web of Science 學科類別Dermatology; DERMATOLOGY

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