beta-sitosterol inhibits high cholesterol-induced platelet beta-amyloid release
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AbstractRecently, increasing evidence has linked high cholesterol to the pathogenesis of Alzheimer's disease (AD), suggesting that cholesterol may be a target for developing new compounds to prevent or treat AD. Plant sterols, a group of sterols enriched in plant oils, nuts, and avocados, have the structure very similar to that of cholesterol, and have been widely used to reduce blood cholesterol. Due to their cholesterol-lowering property, plant sterols such as beta-sitosterol may also influence cholesterol-depending functions including its role in AD development. Using human platelets, a type of peripheral blood cells containing the most circulating amyloid precursor protein (APP), this study investigated the effect of beta-sitosterol on high cholesterol-induced secretion of beta amyloid protein (A beta). It was found that beta-sitosterol effectively inhibited high cholesterol-driven platelet A beta release. In addition, beta-sitosterol prevented high cholesterol-induced increase of activities of beta- and gamma-secretase, two APP cleaving enzymes to generate A beta. Additional experiments showed that high cholesterol up-regulated lipid raft cholesterol. This effect of cholesterol could be suppressed by beta-sitosterol. These findings suggest that beta-sitosterol is able to inhibit high cholesterol-induced A beta release probably through maintenance of membrane cholesterol homeostasis. Given that dietary plant sterols have the potential of penetrating the blood-brain barrier (BBB), these data suggest that plant sterols such as beta-sitosterol may be useful in AD prevention.
All Author(s) ListShi C, Liu J, Wu FM, Zhu XM, Yew DT, Xu J
Journal nameJournal of Bioenergetics and Biomembranes
Detailed descriptionTo ORKTS: doi: 10.1007/s10863-011-9383-2
Year2011
Month12
Day1
Volume Number43
Issue Number6
PublisherSPRINGER/PLENUM PUBLISHERS
Pages691 - 697
ISSN0145-479X
LanguagesEnglish-United Kingdom
Keywordsbeta amyloid protein (A beta); beta-sitosterol; Cholesterol; Plant sterols; Platelets
Web of Science Subject CategoriesBiophysics; BIOPHYSICS; Cell Biology; CELL BIOLOGY

Last updated on 2021-24-01 at 02:07