Phthalocyanine -Polyamine Conjugates as Highly Efficient Photosensitizers for Photodynamic Therapy
Publication in refereed journal


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摘要A series of silicon(IV) phthalocyanines substituted axially with different polyamine moieties have been prepared Their fluorescence quantum yields (Phi(F) = 0 03-0 08) in N,N-dimethylformamide are low because of reductive quenching by the amino moieties The values are significantly increased in aqueous media (Phi(F) = 0 12-0 21) as a result of protonation of the amino substituents All the compounds are highly photocytotoxic against human colon adenocarcinoma HT29 cells and Chinese hamster ovary cells with IC(50) values as low as 1 1 nM Flow cytometric studies of two selected compounds (2 and 5) against H 129 cells have shown that they induce apoptosis extensively As shown by confocal microscopy, these two compounds also show high affinity toward the lysosomes, but not the mitochondria, of the cells Their in vivo photodynamic activity has also been investigated using HT29 tumor bearing nude mice Both of them can effectively inhibit the growth of the tumor without causing apparent injury to the liver of the mice
著者Jiang XJ, Yeung SL, Lo PC, Fong WP, Ng DKP
期刊名稱Journal of Medicinal Chemistry
出版年份2011
月份1
日期13
卷號54
期次1
出版社AMER CHEMICAL SOC
頁次320 - 330
國際標準期刊號0022-2623
電子國際標準期刊號1520-4804
語言英式英語
Web of Science 學科類別Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy

上次更新時間 2020-21-10 於 00:30