Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats
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AbstractPropofol, an anesthetic drug, has been shown to exhibit antioxidant and anti-inflammatory properties in vitro and in vivo. Hypercoagulopathy is a common clinical feature of sepsis, but the effects of propofol on the coagulation system in septic conditions are unclear. Using the gel-based comparative proteomic approach, together with Western blot analysis, ELISA, antithrombin Ill activity assay, and blood coagulation test, the effect of propofol on serum proteomic profiles in endotoxemic rats was examined. We identified that serum platelet factor-4 (PF4). an endogenous pro-coagulant, was up-regulated in LPS-challenged rats (p<0.001). Endotoxemia also resulted in hypercoagulopathy as evidenced by the shortening of thromboplastin time and thrombin time. Administration of propofol attenuated LPS-stimulated PF4 release and partially reversed the effect of LPS on thromboplastin time (p=0.0012) and thrombin time (p=0.0072). We demonstrated that propofol reduces serum levels of PF4 and partially corrects the hypercoagulopathy associated with endotoxemia in rats. (C) 2010 Elsevier B.V. All rights reserved.
All Author(s) ListTang J, Sun YJ, Wu WKK, Zhong TY, Liu YW, Xiao JF, Tao T, Zhao ZL, Gu MN
Year2010
Month9
Day1
Volume Number1804
Issue Number9
PublisherELSEVIER SCIENCE BV
Pages1895 - 1901
ISSN1570-9639
eISSN0006-3002
LanguagesEnglish-United Kingdom
Keywords2D gel electrophoresis; Lipopolysaccharides; Platelet factor 4; Propofol; Rats
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS

Last updated on 2020-20-10 at 02:17