Proton pump inhibitor and clopidogrel interaction: The case for watchful waiting
Publication in refereed journal


Times Cited
Web of Science2WOS source URL (as at 20/09/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractClopidogrel is an integral part of the management of several important vascular diseases. However the medium to long term clinical outcomes are poorer for these patients if they experience gastro-intestinal bleeding, hence patients with risk factors for gastro-intestinal bleeding are frequently prescribed proton pump inhibitors. Conflicting evidence exists as to the existence of an adverse interaction between clopidogrel and proton pump. This review examines the original studies, which suggested the adverse interaction, the subsequent and most recent studies, the pharmaco-dynamics of the two drugs and suggests an algorithm for the use of clopidogrel with proton pump inhibitors.
All Author(s) ListTan VP, Yan BP, Hunt RH, Wong BCY
Journal nameJournal of Gastroenterology and Hepatology
Year2010
Month8
Day1
Volume Number25
Issue Number8
PublisherWILEY-BLACKWELL
Pages1342 - 1347
ISSN0815-9319
eISSN1440-1746
LanguagesEnglish-United Kingdom
Keywordsclopidogrel; gastro-intestinal bleeding; proton pump inhibitors
Web of Science Subject CategoriesGastroenterology & Hepatology; GASTROENTEROLOGY & HEPATOLOGY

Last updated on 2020-21-09 at 00:36