3,3 ',4,5,5 '-pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress
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摘要Resveratrol exhibits anti-tumor properties against different types of cancer. In this study, several polyhydroxylated resveratrol derivatives were prepared with the aim of discovering new leading compounds with clinical potential for human colon cancer chemotherapy. Among these compounds, 3,3',4,5,5'-pentahydroxy-trans-stilbene (PHS) displayed the most potent cytotoxicity and triggered apoptosis in HT-29 cells as evidenced by increased poly(ADP-ribose) polymerase (PARP) cleavage, elevated levels of cytoplasmic nucleosomes and DNA fragmentation. Further mechanistic analysis revealed that PHS-induced apoptosis was caspase-dependent and mediated by its pro-oxidative action through up-regulation of reactive oxidative species generation and depletion of intracellular glutathione. (C) 2010 Elsevier B.V. All rights reserved.
著者Li HT, Wu WKK, Zheng ZP, Che CT, Li ZJ, Xu DD, Wong CCM, Ye CG, Sung JJY, Cho CH, Wang MF
期刊名稱European Journal of Pharmacology
詳細描述(CHC is Co-corresponding author)\n\nTo ORKTS: doi: 10.1016/j.ejphar.2010.04.009
出版年份2010
月份7
日期10
卷號637
期次1-3
出版社ELSEVIER SCIENCE BV
頁次55 - 61
國際標準期刊號0014-2999
電子國際標準期刊號1879-0712
語言英式英語
關鍵詞Apoptosis; Colon cancer; Hydroxylated resveratrol derivative; Oxidative stress
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-21-10 於 00:24