3,3 ',4,5,5 '-pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress
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AbstractResveratrol exhibits anti-tumor properties against different types of cancer. In this study, several polyhydroxylated resveratrol derivatives were prepared with the aim of discovering new leading compounds with clinical potential for human colon cancer chemotherapy. Among these compounds, 3,3',4,5,5'-pentahydroxy-trans-stilbene (PHS) displayed the most potent cytotoxicity and triggered apoptosis in HT-29 cells as evidenced by increased poly(ADP-ribose) polymerase (PARP) cleavage, elevated levels of cytoplasmic nucleosomes and DNA fragmentation. Further mechanistic analysis revealed that PHS-induced apoptosis was caspase-dependent and mediated by its pro-oxidative action through up-regulation of reactive oxidative species generation and depletion of intracellular glutathione. (C) 2010 Elsevier B.V. All rights reserved.
All Author(s) ListLi HT, Wu WKK, Zheng ZP, Che CT, Li ZJ, Xu DD, Wong CCM, Ye CG, Sung JJY, Cho CH, Wang MF
Journal nameEuropean Journal of Pharmacology
Detailed description(CHC is Co-corresponding author)\n\nTo ORKTS: doi: 10.1016/j.ejphar.2010.04.009
Year2010
Month7
Day10
Volume Number637
Issue Number1-3
PublisherELSEVIER SCIENCE BV
Pages55 - 61
ISSN0014-2999
eISSN1879-0712
LanguagesEnglish-United Kingdom
KeywordsApoptosis; Colon cancer; Hydroxylated resveratrol derivative; Oxidative stress
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2021-18-04 at 23:58