A small molecule inhibitor of NF-kappa B, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells
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摘要Despite the demonstrated constitutive activation of NF-kappa B in nasopharyngeal carcinoma (NPC), the therapeutic potential of targeting this pathway has not been investigated. Here, we employed a small molecule inhibitor of NF-kappa B, DHMEQ (which mainly blocks nuclear translocation of activated NF-kappa B) and demonstrated significant inhibition of NPC cell proliferation, migration, invasion, as well as anchorage-independent growth. These antitumor effects were associated with induction of G(2)/M cell cycle arrest and apoptosis, and down-regulation of NF-kappa B target genes (EGFR, cyclin D1 and survivin). This first demonstration of therapeutic benefits of NF-kappa B targeting in NPC implicates the importance of targeting this pathway in NPC. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
著者Wong JHT, Lui VWY, Umezawa K, Ho Y, Wong EYL, Ng MHL, Cheng SH, Tsang CM, Tsao SW, Chan ATC
期刊名稱Cancer Letters
詳細描述Epub ahead of print.
出版年份2010
月份1
日期1
卷號287
期次1
出版社ELSEVIER IRELAND LTD
頁次23 - 32
國際標準期刊號0304-3835
電子國際標準期刊號1872-7980
語言英式英語
關鍵詞Anti-invasion; Anti-proliferation; Apoptosis; DHMEQ; Nasopharyngeal carcinoma; NF-kappa B inhibitor
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2020-28-10 於 00:57