Light-activated hypericin induces cellular destruction of nasopharyngeal carcinoma cells
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AbstractHypericin from Hypericum perforatum plants shows an important promise in the photodynamic therapy on malignant tumor, The present study investigated that light-activated hypericin induced the cellular destruction of nasopharyngeal carcinoma cells. The result showed that hypericin resulted in a drug- and light-dose dependent cytotoxicity in the CNE-2 cells, meaning the photocytotoxicity of hypericin depends on both of the drug concentration (0-2.5 mu M) and light-doses (1-8 J/cm(2)). We further investigated the apoptosis of the CNE-2 cells 8 hours after photosensitization of hypericin using fluorescence microscopy with Hoechst 33258 staining. Flow cytometry with annexin V-FITC and PI staining was used to analyze early and late apoptosis. These data demonstrated that light-activated hypericin could significantly lead to (be cellular destruction of the CNE-2 cells and induce early apoptosis as a prominent mode of cell death.
All Author(s) ListXu CS, Leung AWN
Journal nameLaser Physics Letters
Volume Number7
Issue Number1
Pages68 - 72
LanguagesEnglish-United Kingdom
Keywordsapoptosis; cellular destruction; hypericin; nasopharyngeal carcinoma; photodynamic action
Web of Science Subject CategoriesOptics; OPTICS; Physics; Physics, Applied; PHYSICS, APPLIED

Last updated on 2020-28-09 at 01:46