Inducible Nucleosome Depletion at OREBP-Binding-Sites by Hypertonic Stress
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AbstractBackground: Osmotic Response Element-Binding Protein (OREBP), also known as TonEBP or NFAT5, is a unique transcription factor. It is hitherto the only known mammalian transcription factor that regulates hypertonic stress-induced gene transcription. In addition, unlike other monomeric members of the NFAT family, OREBP exists as a homodimer and it is the only transcription factor known to bind naked DNA targets by complete encirclement in vitro. Nevertheless, how OREBP interacts with target DNA, also known as ORE/TonE, and how it elicits gene transcription in vivo, remains unknown.
All Author(s) ListTong EHY, Guo JJ, Xu SX, Mak K, Chung SK, Chung SSM, Huang AL, Ko BCB
Journal namePLoS ONE
Volume Number4
Issue Number12
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesMultidisciplinary Sciences; MULTIDISCIPLINARY SCIENCES; Science & Technology - Other Topics

Last updated on 2021-25-11 at 00:06