Age distribution of human papillomavirus infection and cervical neoplasia reflects caveats of cervical screening policies
Publication in refereed journal


摘要Although a second age-related peak of human papillomavirus (HPV) infection is observed in many populations, it does not seem to have any impact on cervical screening policies. We examined the age-specific prevalence of HPV infection among 2,604 women enrolled for cervical screening and correlated the age at diagnosis of 2,491 cervical intraepithelial neoplasia Grade 2/3 (CIN2/3) lesions and 801 invasive cervical cancers (ICC). Two peaks of HPV infection were detected at 26-30 and 46-50 years, respectively. The first infection peak was followed by a CIN2/3 peak and an ICC peak at 5-15 and 15 years later, respectively. The second infection peak was followed by an ICC peak 20 years later, but strikingly no CIN2/3 peak was detected in between and thus eliminated an opportunity of treating the lesions at preinvasive stages. The most plausible explanation is that women at the expected second CIN2/3 peak (50-65 years) are not having Pap smears under the current opportunistic screening program. Furthermore, women of this age may have physiological retraction of the transformation zone, and CIN lesions may remain undetected if an adequate Pap smear sample is not obtained. To combat this problem, the screening program in Hong Kong needs to focus on women aged 50 years and older and a mop-up screening up to 75 years is necessary. Bimodal peaks of HPV infection and cervical cancer are seen in many countries and the analysis of population-specific age distribution of CIN2/3 should be an integral exercise in evaluating the effectiveness of a screening program.
著者Chan PKS, Chan AR, Yu MY, Li WH, Chan MYM, Yeung ACM, Cheung TH, Yau TN, Wong SM, Yau CW, Ng HK
期刊名稱International Journal of Cancer
頁次297 - 301
關鍵詞age; cervical cancer; cervical intraepithelial neoplasia; Chinese; Hong Kong; human papillomavirus; Pap smear; screening
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-24-01 於 02:03