Folic Acid Supplementation Modifies beta-Adrenoceptor-Mediated In Vitro Lipolysis of Obese/Diabetic (+db/+db) Mice
Publication in refereed journal

Times Cited
Web of Science7WOS source URL (as at 14/09/2020) Click here for the latest count
Altmetrics Information

Other information
AbstractThe effects of folic acid (5.7 and 71 mu g/kg, 4 weeks) consumption on the beta-adrenoceptors (beta-ARs)-elicited lipolysis in vitro of the abdominal adipocytes of lean/control (+ml+db) and obese/diabetic (+dbl+db) mice (female) were investigated. beta-AR agonists (salbutamol, a beta(2)-AR agonist; BRL 37344 and CGP 12177, beta(3)-AR agonists; adrenaline, a beta-AR agonist-mediated lipolysis, beta(2)-, and beta(3-)ARs protein expression of the adipose tissues after folic acid consumption were evaluated. Our results demonstrate that a smaller magnitude of the basal (spontaneous) and the beta-AR agonists-triggered lipolysis was observed in +dbt+db mice, and folic acid supplementation (71 mu g/kg) resulted in an improvement of both the baseline and the beta-ARs-mediated lipolysis. In controls, a lower beta(2)- and beta(3)-ARs protein expression of the adipose tissues was detected in +dbl+db mice, compared to +ml+db mice. In both strains fed with folic acid (71 mu g/kg), a reduction of beta(2)-AR protein expression was observed compared to the respective controls. In +dbl+db mice, folic acid (5.7 and 71 mu g/kg) consumption caused a dose-dependent increase of beta(3)-AR protein expression compared to controls. We demonstrate that lipolysis elicited by beta-AR (beta(2)- and beta(3)-ARs) agonists was blunted in +dbl+db mice. Folic acid consumption has significant modulatory effects on beta-ARs protein expression and lipolysis. Exp Biol Med 234:1047-1055, 2009
All Author(s) ListLam TY, Seto SW, Au ALS, Poon CCW, Li RWS, Lam HY, Lau WS, Chan SW, Ngai SM, Leung GPH, Lee SMY, Tsui SKW, Kwan YW
Journal nameExperimental Biology and Medicine
Volume Number234
Issue Number9
Pages1047 - 1055
LanguagesEnglish-United Kingdom
Keywords+db/ plus db mice; adipocytes; beta-adrenoceptor; folic acid; lipolysis
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine

Last updated on 2020-15-09 at 03:14