Antiviral Constituents against Respiratory Viruses from Mikania micrantha
Publication in refereed journal


Times Cited
Web of Science15WOS source URL (as at 13/09/2021) Click here for the latest count
Altmetrics Information
.

Other information
AbstractPhytochemical investigation of the dried aerial parts of Mikania micrantha led to the isolation of a new sesquiterpene, 3 beta-acetoxy-1,10-epoxy-4-germacrene-12,8;15,6-diolide (1), along with six known constituents: 1,10-epoxy-4-germacrene-12,8;15,6-diolide (2), dihydromikanolide (3), potassium mikanin 3-sulfate (4), mikanin (5), alpinetin (6), and ergosta-7,22-dien-3 beta-ol (7). Their structures were elucidated by spectroscopic methods, and the molecular structures and stereochemistry of sesquiterpene lactones 1-3 were revealed by single-crystal X-ray analysis. Compound 2 showed moderate activity against respiratory syncytial virus (IC(50) = 37.4 uM) and parainfluenza type 3 virus (IC50 = 37.4 uM) with a therapeutic index (TI) of 16.0 for both compounds. Compound 4, the main component of M. micrantha, exhibited inhibitory activity against parainfluenza type 3 virus with IC(50) (19.7 uM) and TI (24.0) values comparable to those of ribavirin, serving as a positive control.
All Author(s) ListBut PPH, He ZD, Ma SC, Chan YM, Shaw PC, Ye WC, Jiang RW
Journal nameJournal of Natural Products
Year2009
Month5
Day1
Volume Number72
Issue Number5
PublisherAMER CHEMICAL SOC
Pages925 - 928
ISSN0163-3864
eISSN1520-6025
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesChemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Plant Sciences; PLANT SCIENCES

Last updated on 2021-13-09 at 23:47