Application of denaturing HPLC to rapidly identify rifampicin-resistant Mycobacterium tuberculosis in low- and high-prevalence areas
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AbstractSince the emergence of multidrug-resistant and extensively drug-resistant tuberculosis, there has been a call for a rapid assay to detect rifampicin-resistant strains that can be implemented into a routine service to analyse all strains in a specific geographical location. Denaturing HPLC (dHPLC) is a rapid screening test that can detect mutations in PCR amplicons. The aim of this study was to evaluate the dHPLC analysis of rifampicin-resistant Mycobacterium tuberculosis isolates using an extensive strain collection from Hong Kong and the UK and a collection of 84 consecutive clinical isolates.
All Author(s) ListEvans JT, Parveen A, Smith GE, Xu L, Chan EWC, Chan RCY, Hawkey PM
Journal nameJournal of Antimicrobial Chemotherapy
Year2009
Month2
Day1
Volume Number63
Issue Number2
PublisherOXFORD UNIV PRESS
Pages295 - 301
ISSN0305-7453
eISSN1460-2091
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesInfectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-31-07 at 01:46