A novel and effective hepatocyte growth factor kringle 1 domain and p53 cocktail viral gene therapy for the treatment of hepatocellular carcinoma
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摘要Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, yet effective therapeutic options for advanced HCC are limited. Kringle 1 domain of HGF (HGFK1) has been demonstrated as a potent anti-tumor molecule and p53 is a well established tumor suppressor. Recently we developed AAV transducing HGFK1 (AAV-HGFK1) as a gene therapy for HCC. Here we investigated the possibility of enhancing the effect of AAV-HGFK1 by combining it with Adv transducing p53 (Adv-p53). In vitro expression experiments suggested a small amount of Adv-p53 could increase the expression of AAV transgenes. AAV-HGFK1 + Adv-p53 cocktail strongly inhibited the proliferation of microvascular endothelial cell (MEC) and two HCC cell lines, Hepa 1-6 and McA-RH7777. In two orthotopic mice and rat HCC models the cocktail gene therapy also significantly reduced the tumor burdens and prolonged the survival time by inhibiting tumor angiogenesis and inducing tumor cell death. Significantly, tumor metastasis was completely prevented. AAV-HGFK1 + Adv-p53 viral cocktail may be a promising cancer therapy for the treatment of HCC. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
著者Shen Z, Wong OGW, Yao RY, Liang J, Kung HF, Lin MCM
期刊名稱Cancer Letters
出版年份2008
月份12
日期18
卷號272
期次2
出版社ELSEVIER IRELAND LTD
頁次268 - 276
國際標準期刊號0304-3835
電子國際標準期刊號1872-7980
語言英式英語
關鍵詞Anti-tumor; Cocktail gene therapy; Hepatocellular carcinoma; HGFK1
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-28-02 於 00:51