Randomised double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective Caesarean section
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摘要In a randomised, double-blinded study, we compared boluses of phenylephrine 100 mu g with ephedrine 10 mg for treating hypotension (systolic blood pressure < 100 mmHg) in 204 patients having non-elective Caesarean section under spinal anaesthesia. Umbilical arterial (UA) and venous (UV) pH and base excess were similar between groups. In the ephedrine group, UA lactate concentration was higher ( median 2.6 [interquartile range 2.3-3.3] vs 2.4 [1.9-3.0] mmol.l(-1), p = 0.002) and UV lactate concentration was higher (2.5 [2.2-3.2] vs 2.3 [1.9-2.8] mmol.l(-1), p = 0.016) and more patients had nausea or vomiting (12.7% vs 3.9%, p = 0.02). Clinical neonatal outcome was similar. Of the protocol-compliant patients (n = 148), UA PO2 and UV PO2 were lower in the phenylephrine group although oxygen content was similar. We conclude that phenylephrine and ephedrine are both suitable vasopressors for use in non-elective Caesarean sections.
著者Ngan Kee WD, Khaw KS, Lau TK, Ng FF, Chui K, Ng KL
期刊名稱Anaesthesia
出版年份2008
月份12
日期1
卷號63
期次12
出版社WILEY-BLACKWELL
頁次1319 - 1326
國際標準期刊號0003-2409
電子國際標準期刊號1365-2044
語言英式英語
Web of Science 學科類別Anesthesiology; ANESTHESIOLOGY

上次更新時間 2020-01-12 於 00:11