Influence of operating teperature and pressure on the polymorphic transition of saimeterol xinafoate in supercritical fluids
Publication in refereed journal

香港中文大學研究人員

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摘要Precipitation of pure polymorphic forms (I and II) of salmeterol xinafoate (SX) in supercritical fluids was investigated as a function of operating pressure and temperature. It has been shown that the formation of each polymorph is governed by both thermodynamic shift and kinetic effects, which are closely associated with the extent of miscibility between the supercritical CO2 and methanol cosolvent. In addition, the surface energetics of SX exhibit a sharp discontinuity at the transition point in concordance with the particular polymorphic form generated, being essentially independent of the temperature or pressure below and above this point. The conditions of complete miscibility of the two solvent phases involved are critical for the formation of SX Form II. (c) 2007 Wiley-Liss, Inc.
著者Tong HHY, Shekunov BY, York P, Chow AHL
期刊名稱Journal of Pharmaceutical Sciences
出版年份2008
月份2
日期1
卷號97
期次2
出版社JOHN WILEY & SONS INC
頁次1025 - 1029
國際標準期刊號0022-3549
電子國際標準期刊號1520-6017
語言英式英語
關鍵詞polymorphic transition; pressure and temperature; salmeterol xinafoate; supercritical fluid crystallization; surface energetics
Web of Science 學科類別Chemistry; Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-15-09 於 03:08