Influence of operating teperature and pressure on the polymorphic transition of saimeterol xinafoate in supercritical fluids
Publication in refereed journal

Times Cited
Web of Science9WOS source URL (as at 15/10/2020) Click here for the latest count
Altmetrics Information

Other information
AbstractPrecipitation of pure polymorphic forms (I and II) of salmeterol xinafoate (SX) in supercritical fluids was investigated as a function of operating pressure and temperature. It has been shown that the formation of each polymorph is governed by both thermodynamic shift and kinetic effects, which are closely associated with the extent of miscibility between the supercritical CO2 and methanol cosolvent. In addition, the surface energetics of SX exhibit a sharp discontinuity at the transition point in concordance with the particular polymorphic form generated, being essentially independent of the temperature or pressure below and above this point. The conditions of complete miscibility of the two solvent phases involved are critical for the formation of SX Form II. (c) 2007 Wiley-Liss, Inc.
All Author(s) ListTong HHY, Shekunov BY, York P, Chow AHL
Journal nameJournal of Pharmaceutical Sciences
Volume Number97
Issue Number2
Pages1025 - 1029
LanguagesEnglish-United Kingdom
Keywordspolymorphic transition; pressure and temperature; salmeterol xinafoate; supercritical fluid crystallization; surface energetics
Web of Science Subject CategoriesChemistry; Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-16-10 at 01:52