Influence of operating teperature and pressure on the polymorphic transition of saimeterol xinafoate in supercritical fluids
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AbstractPrecipitation of pure polymorphic forms (I and II) of salmeterol xinafoate (SX) in supercritical fluids was investigated as a function of operating pressure and temperature. It has been shown that the formation of each polymorph is governed by both thermodynamic shift and kinetic effects, which are closely associated with the extent of miscibility between the supercritical CO2 and methanol cosolvent. In addition, the surface energetics of SX exhibit a sharp discontinuity at the transition point in concordance with the particular polymorphic form generated, being essentially independent of the temperature or pressure below and above this point. The conditions of complete miscibility of the two solvent phases involved are critical for the formation of SX Form II. (c) 2007 Wiley-Liss, Inc.
All Author(s) ListTong HHY, Shekunov BY, York P, Chow AHL
Journal nameJournal of Pharmaceutical Sciences
Year2008
Month2
Day1
Volume Number97
Issue Number2
PublisherJOHN WILEY & SONS INC
Pages1025 - 1029
ISSN0022-3549
eISSN1520-6017
LanguagesEnglish-United Kingdom
Keywordspolymorphic transition; pressure and temperature; salmeterol xinafoate; supercritical fluid crystallization; surface energetics
Web of Science Subject CategoriesChemistry; Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-16-10 at 01:52