A T2*magnetic resonance imaging study of pancreatic iron overload in thalassemia major
Publication in refereed journal

香港中文大學研究人員

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摘要We studied the utility of pancreatic magnetic resonance imaging (MRI) in 72 thalassemia major patients (21 diabetic, 51 normoglycemic). Diabetic patients were significantly older (p<0.0001) and had smaller pancreas volume (p<0.0001). The two groups were comparable for ferritin and MRI-T2* heart, liver and pancreas. Pancreatic T2* signals were abnormal in 80% of both groups, and correlated with heart T2*. In normoglycemic patients, cardiac T2* and log-pancreatic T2* values correlated with homeostatic model assessments HOMA-B (beta cell reserve), HOMA-IR (insulin resistance) and fasting insulin/C-peptide levels. This suggested that improved chelation may improve P cell reserve and prevent pancreatic atrophy.
著者Au WY, Lam WWM, Chu W, Tam S, Wong WK, Liang R, Ha SY
期刊名稱Haematologica
出版年份2008
月份1
日期1
卷號93
期次1
出版社FERRATA STORTI FOUNDATION
頁次116 - 119
國際標準期刊號0390-6078
語言英式英語
關鍵詞magnetic resonance; thalassemia
Web of Science 學科類別Hematology; HEMATOLOGY

上次更新時間 2020-18-11 於 23:43