The adsorption of vancomycin by polyacrylonitrile, polyamide, and polysulfone hemofilters
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摘要The aim of this study was to characterize vancomycin adsorption by polyacrylonitrile (PAN), polyamide, and polysulfone hemofilters using an in vitro model of hemofiltration. Vancomycin (36 mg) was added to a blood-crystalloid mixture of known volume (target concentration of 50 mg/L) and pumped around a closed circuit. Adsorption, which was calculated from the fall in concentration over 120 min, was significantly greater by 0.6-m(2) PAN filters (10.08 +/- 2.26 mg) than by 0.6-m(2) polyamide (5.20 +/- 1.82 mg) or 0.7-m(2) polysulfone (4.80 +/- 2.40 mg) filters (P < 0.05). Cumulative adsorption was not changed by the addition of 500-mL lactated Ringer's solution (to reduce the circulating vancomycin concentration). These data show that although adsorption of vancomycin by PAN, polyamide, and polysulfone hemofilters occurs, the absolute adsorption is small. Adsorption is dependent on filter material and is not reversed by a decrease in circulating concentration.
著者Tian Q, Gomersall CD, Leung PPN, Choi GYS, Joynt GM, Tan PE, Wong ASY
期刊名稱Artificial Organs
出版年份2008
月份1
日期1
卷號32
期次1
出版社BLACKWELL PUBLISHING
頁次81 - 84
國際標準期刊號0160-564X
語言英式英語
關鍵詞adsorption; hemofiltration; kidney failure; pharmacokinetics; renal replacement therapy; vancomycin
Web of Science 學科類別Engineering; Engineering, Biomedical; ENGINEERING, BIOMEDICAL; Transplantation; TRANSPLANTATION

上次更新時間 2021-10-05 於 03:16