Value of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections
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摘要The values of procalcitonin (PCT), neopterin, and C-reactive protein (CRP) alone and in combination to differentiate bacterial from viral etiology in patients with lower respiratory tract infections (LRTIs) were evaluated. Sera obtained on the day of hospitalization for LRTI from 139 patients with confirmed bacterial etiology and 128 patients with viral etiology were examined. A further 146 sera from healthy Chinese subjects with no infection were included as controls. The area under the receiver operating characteristic (ROC) curve (area under curve [AUC]) for distinguishing bacterial from viral infections was 0.838 for CRP and 0.770 for PCT (P < 0.05). The AUC for distinguishing viral from bacterial infections was 0.832 for neopterin (P < 0.05). When the markers were used in combination, AUC of ROC (CRP/neopterin) was 0.857, whereas (CRP x PCT)/neopterin was 0.856. Combination of 2 or all 3 of the biomarkers may improve the discriminatory power in delineating bacterial versus viral etiology in LRTI. (C) 2007 Elsevier Inc. All rights reserved.
著者Ip M, Rainer TH, Lee N, Chan C, Chau SSL, Leung W, Leung MF, Tam TK, Antonio GE, Lui G, Lau TK, Hui DSC, Fuchs D, Renneberg R, Chan PKS
期刊名稱Diagnostic Microbiology and Infectious Disease
出版年份2007
月份10
日期1
卷號59
期次2
出版社ELSEVIER SCIENCE INC
頁次131 - 136
國際標準期刊號0732-8893
語言英式英語
關鍵詞C-reactive protein; CRP; lower respiratory tract infection (LRTI); neopterin; pneumonia; procalcitonin
Web of Science 學科類別Infectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY

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