Genetic association study of growth hormone receptor and idiopathic scoliosis
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AbstractAlthough the etiology of scoliosis is multifactorial, genetic factors play an important role. Recent linkage studies on familial idiopathic scoliosis revealed multiple putative predisposition loci. A genetic association study is complementary to linkage studies in defining the genetic basis of complex traits of diseases like idiopathic scoliosis. The onset and progression of adolescent idiopathic scoliosis is a manifestation of aberrant growth in the spine. Meanwhile, a high proportion of patients with adolescent idiopathic scoliosis have additional phenotypes, which suggest systemic growth dysregulation during puberty. The growth hormone-insulin-like growth factor axis plays the principle role in skeletal growth regulation. Because growth hormone receptor alleles were associated with body stature and response to growth hormone treatment, we hypothesized the growth hormone receptor is a candidate predisposing and disease modifier gene for adolescent idiopathic scoliosis. Five hundred ten girls with adolescent idiopathic scoliosis and 363 normal subjects were recruited. Curve severity, arm span, and bone mineral densities were recorded. Five polymorphisms were studied by polymerase chain reaction-restriction fragment length polymorphism. All the genotype and allele frequencies were comparable between groups. The Cobb angles among patients of different genotypes were similar. The growth hormone receptor did not appear to be a predisposing gene or disease modifier gene of adolescent idiopathic scoliosis.
All Author(s) ListQiu XS, Tang NLS, Yeung HY, Qiu Y, Cheng JCY
Journal nameClinical Orthopaedics and Related Research
Detailed descriptionPMID: 17514010 . DOI: 10.1097/BLO.0b013e3180986dc2
Year2007
Month9
Day1
Issue Number462
PublisherLIPPINCOTT WILLIAMS & WILKINS
Pages53 - 58
ISSN0009-921X
eISSN1528-1132
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesOrthopedics; ORTHOPEDICS; Surgery; SURGERY

Last updated on 2020-31-07 at 01:38