Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor
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AbstractBackground and purpose: Angiogenesis is a crucial step in tumour growth and metastasis. Ginsenoside-Rb1 ( Rb1), the major active constituent of ginseng, potently inhibits angiogenesis in vivo and in vitro. However, the underlying mechanism remains unknown. We hypothesized that the potent anti-angiogenic protein, pigment epithelium-derived factor ( PEDF), is involved in regulating the anti-angiogenic effects of Rb1.
All Author(s) ListLeung KW, Cheung LWT, Pon YL, Wong RNS, Mak NK, Fan TPD, Au SCL, Tombran-Tink J, Wong AST
Journal nameBritish Journal of Pharmacology
Year2007
Month9
Day1
Volume Number152
Issue Number2
PublisherNATURE PUBLISHING GROUP
Pages207 - 215
ISSN0007-1188
eISSN1476-5381
LanguagesEnglish-United Kingdom
Keywordsangiogenesis; endothelial cells; ginseng; oestrogen receptor; PEDF
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2021-28-02 at 00:30