RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma
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摘要The X protein of hepatitis B virus (HBx) is often expressed in human hepatocellular carcinoma (HCC) but its role on tumor growth is not fully clarified. In this study, RNA interference was employed to knockdown HBx expression in Hep3B HCC cells, which naturally express carboxyl-end truncated form of HBx frequently found in HCC tissues. Specific knockdown of HBx strongly inhibited cell growth and tumorigenicity in xenograft model. HBx repression induced apoptosis in Hep3B cells and significantly increased cell sensitivity to cisplatin-induced apoptosis. These results suggest that RNA interference-mediated HBx suppression exerts potent anti-proliferative and chemosensitizing effects in human HCC. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
著者Cheng ASL, Wong N, Tse AMY, Chan KYY, Chan KK, Sung JJY, Chan HLY
期刊名稱Cancer Letters
出版年份2007
月份8
日期8
卷號253
期次1
出版社ELSEVIER IRELAND LTD
頁次43 - 52
國際標準期刊號0304-3835
電子國際標準期刊號1872-7980
語言英式英語
關鍵詞chemosensitivity; cisplatin; HBx; hepatocellular carcinoma; RNAi
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2020-20-09 於 01:28