Fentanyl dose-response curves when inserting the LMA Classic((TM)) laryngeal mask airway
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摘要Probit analysis was used to predict an optimal dose of fentanyl, co-administered with propofol 2.5 mg.kg(-1), when inserting the laryngeal mask airway. In all, 21 male and 54 female healthy Chinese patients, aged 18-63 years, requiring anaesthesia for minor surgery were recruited. They were assigned to one of five groups: placebo, 0.5, 1.0, 1.5 and 2.0 mu g.kg(-1). Insertion was performed 90 s after administration and insertion conditions assessed using a six-category score. Dose-response curves could only be drawn for swallowing and movement categories, and only the ED50 could be predicted with certainty. To provide optimal conditions in over 95% of patients, fentanyl doses well above the clinical range were required. A standard fentanyl dose of 1 mu g.kg(-1), co-administered with propofol 2.5 mg.kg(-1), provided optimal conditions in 65% of cases. Ninety seconds may have been insufficient time for fentanyl to reach its peak effect.
著者Wong CM, Critchley LA, Lee A, Khaw KS, Kee WDN
會議名稱Combined Scientific Meeting in Anaesthesiology
會議開始日27.08.2005
會議完結日28.08.2005
會議地點Hong Kong
期刊名稱Anaesthesia
出版年份2007
月份7
日期1
卷號62
期次7
出版社Wiley: 12 months
頁次654 - 660
國際標準期刊號0003-2409
電子國際標準期刊號1365-2044
語言英式英語
Web of Science 學科類別Anesthesiology; ANESTHESIOLOGY

上次更新時間 2020-03-12 於 23:20