Migration of bone marrow stem cells in ischaemic brain
Refereed conference paper presented and published in conference proceedings


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AbstractStem cell therapy has been demonstrated to be effective in the management of haematological malignancy and solid cancer, but its role in neurodegenerative conditions remains uncertain. We hypothesize that: (1) ventricular delivery of bone marrow stein cells improves functional outcome in experimental ischaemia of the mouse brain; and (2) this improved outcome is due to migration of bone marrow stein cells to areas of ischaemia. Twelve mice with transient cerebral hemisphere ischaemia were randomly allocated to receive bone marrow stem cells or saline. The six animals that underwent cell therapy were found to perform better and committed fewer errors in the water maze system compared with the six control mice. Migration of these bone marrow stem cells was evident within the ventricular cerebro-spinal fluid (CSF) system and the brain parenchyma. This could also occur in clusters of cells. Preferential migration of these cells took place in lesioned areas.
All Author(s) ListPoon WS, Lu G, Tsang KS, Zhu XL, Chen GG, Ng HK
Name of Conference1st Congress of the International-Society-of-Reconstructive-Neurosurgical-Societies
Start Date of Conference01/09/2005
End Date of Conference03/09/2005
Place of ConferenceSeoul
Country/Region of ConferenceSouth Korea
Journal nameActa Neurochirurgica -Supplementum then Supplement- Wien-
Year2006
Month1
Day1
Volume Number99
PublisherSPRINGER-VERLAG WIEN
Pages123 - 124
ISBN*************
ISSN0065-1419
LanguagesEnglish-United Kingdom
Keywordsbone marrow stem cells; cerebral ischaemia; water maze system
Web of Science Subject CategoriesClinical Neurology; Neurosciences & Neurology; Surgery

Last updated on 2021-19-01 at 00:46