Localization of hyaluronan in the optic pathway of mouse embryos
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AbstractCD44 has been shown to be involved in midline crossing and the generation of ipsilateral projections in the mouse optic chiasm. To determine whether these functions involve hyaluronan, the major ligand of CD44, we examined localization of hyaluronan in the mouse optic pathway. Hyaluronan was deposited mainly in vitreal regions of the retina and the optic disk. In ventral diencephalon, it was localized largely on the chiasmatic neurons that project processes to the chiasmatic midline and the optic tract. Colocalization of hyaluronan and CD44 was observed only in the midline but not lateral domains of the chiasmatic neurons, suggesting a hyaluronan/CD44-mediated mechanism that controls axon routing at the midline but not at the optic tract and the retina.
All Author(s) ListLin L, Wang J, Chan CK, Chan SO
Journal nameNeuroReport
Volume Number18
Issue Number4
Pages355 - 358
LanguagesEnglish-United Kingdom
Keywordsaxon guidance; CD44; extracellular matrix; midline; retina
Web of Science Subject CategoriesNeurosciences; NEUROSCIENCES; Neurosciences & Neurology

Last updated on 2020-08-07 at 03:45