Establishing CD4 thresholds for highly active antiretroviral therapy initiation in a cohort of HIV-infected adult Chinese in Hong Kong
Publication in refereed journal


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摘要Studies on the use and outcome of highly active antiretroviral therapy (HAART) in HIV-infected Chinese have been scarce. We evaluated risk of progression to (1) nonaccidental death and (2) new AIDS-defining illness (ADI) or death in 223, 89.9% of 248 HIV-1-infected adult Chinese patients who were first initiated on HAART between 1997 and 2002, and followed through 2003. The study subjects were mostly male (88.3%), aged between 30-49 years (43.9%), and acquired HIV via sexual contact (95.7%). After a median follow-up of 38.6 months, 13 nonaccidental deaths were observed. Overall, 25 patients developed new ADI or died. Using Kaplan-Meier analyses, there was no survival difference of starting HAART at various CD4 strata but a higher risk of progression to new ADI/death in patients with pretreatment CD4 count less than 100 cells per microliter (p = 0.01). On Cox proportional hazards multivariate regression analyses, pretreatment CD4 counts of less than 100 cells per microliter and less than 150 cells per microliter but not higher levels were the cutoffs for increased progression to death (adjusted hazard ratio [HR] = 4.90, 95% confidence interval [CI]: 1.08-22.22) and new ADI/death (adjusted HR = 14.44, 95% CI: 1.95-106.89), respectively. Age 50 years or greater was the only other independent predictor of mortality and new ADI/death after HAART. Further studies are indicated to validate and discern implications of these preliminary findings of a lower CD4 threshold for antiretroviral therapy in a small Chinese HIV cohort.
著者Wong KAH, Chan KCW, Cheng KLS, Chan WK, Kam KM, Lee SS
會議名稱44th Interscience Conference on Antimicrobial Agents and Chemotherapy
會議開始日30.10.2004
會議完結日02.11.2004
會議地點Washington
期刊名稱AIDS Patient Care and STDs
出版年份2007
月份2
日期1
卷號21
期次2
出版社MARY ANN LIEBERT INC
頁次106 - 115
國際標準期刊號1087-2914
電子國際標準期刊號1557-7449
語言英式英語
Web of Science 學科類別Infectious Diseases; INFECTIOUS DISEASES; Public, Environmental & Occupational Health; PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SSCI

上次更新時間 2021-10-05 於 02:59