Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma
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摘要Deletion of the short arm of chromosome 3 is a common event in nasopharyngeal carcinoma (NPC), suggesting that one or more tumor suppressor genes at 3p are involved in this cancer. DLEC1, Deleted in Lung and Esophageal Cancer I, located at 3p22.2, was recently identified as a candidate tumor suppressor gene in lung, esophageal, and renal cancers. In this study, we investigated the involvement of DLEC1 in the development of NPC. Down-regulation of DLEC1 and promoter hypermethylation were observed in all NPC cell lines and xenografts but not in normal nasopharyngeal epithelial cells. Promoter hypermethylation of DLEC1 was also detected in 30 of 42 (71%) NPC primary tumors. Treatment of NPC cell lines with demethylating agent or histone deacetylase inhibitor resulted in restoration of DLEC1 expression. Overexpression of DLEC suppressed growth and reduced invasiveness of NPC cells. Furthermore, the tumorigenic potential of DLEC1 expressing NPC cells was highly reduced in nude mice. Taken together, our results strongly suggest that silencing of DLEC1 expression by promoter hypermethylation and histone deacetylation may be important in NPC tumorigenesis. (c) 2006 Wiley-Liss, Inc.
著者Kwong J, Chow LSN, Wong AYH, Hung WK, Chung GTY, To KF, Chan FL, Daigo Y, Nakamura Y, Huang DP, Lo KW
期刊名稱Genes, Chromosomes and Cancer
出版年份2007
月份2
日期1
卷號46
期次2
出版社WILEY-LISS
頁次171 - 180
國際標準期刊號1045-2257
語言英式英語
Web of Science 學科類別Genetics & Heredity; GENETICS & HEREDITY; Oncology; ONCOLOGY

上次更新時間 2020-23-10 於 00:22