Altered expression of serum protein in ginsenoside Re-treated diabetic rats detected by SELDI-TOF MS
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摘要Diabetes mellitus (DM) is now a global health problem, however, its pathogenesis has not yet been fully deciphered. Even though modem medicine has great contribution to the control and treatment of DM, it is still far from success to completely cure the disease. Panax ginseng C.A. Meyer (ginseng) is a well-recognized traditional Chinese medicine for treating DM in Asia. In this study, high throughput proteomic approach has been adopted to investigate the antidiabetic action of 2 weeks' ginsenoside Re (Re, a major component of ginseng) administration to streptozotocin-induced diabetic rats. Employing surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) and bioinformatics, 432 cluster peaks were detected in the samples, among them 293 potential biomarkers were found to have significant differentiations between the DM and control normal rats. When the Re-treated diabetic rats were compared to the untreated ones, a protein peak was detected to have significant alteration corresponding to Re treatment. This specific protein was found to match with C-reactive protein (CRP) in the protein database, and was subsequently validated by ELISA. This is the first study demonstrated that CRP could be altered by Re treatment, indicating that Re may improve diabetes and its complications by alleviation of inflammation. (c) 2006 Elsevier Ireland Ltd. All fights reserved.
著者Cho WCS, Yip TT, Chung WS, Lee SKW, Leung AWN, Cheng CHK, Yue KKM
期刊名稱Journal of Ethnopharmacology
出版年份2006
月份11
日期24
卷號108
期次2
出版社ELSEVIER IRELAND LTD
頁次272 - 279
國際標準期刊號0378-8741
語言英式英語
關鍵詞C-reactive protein; diabetes mellitus; ginsenoside Re; Panax ginseng; SELDI-TOF MS; traditional Chinese medicine
Web of Science 學科類別Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Integrative & Complementary Medicine; INTEGRATIVE & COMPLEMENTARY MEDICINE; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Plant Sciences; PLANT SCIENCES

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