HTRA1 promoter polymorphism in wet age-related macular degeneration
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AbstractAge-related macular degeneration (AMD), the most common cause of irreversible vision loss in individuals aged older than 50 years, is classified as either wet (neovascular) or dry (nonneovascular). Inherited variation in the complement factor H gene is a major risk factor for drusen in dry AMD. Here we report that a single-nucleotide polymorphism in the promoter region of HTRA1, a serine protease gene on chromosome 10q26, is a major genetic risk factor for wet AMD. A whole-genome association mapping strategy was applied to a Chinese population, yielding a P value of < 10(-11). Individuals with the risk-associated genotype were estimated to have a likelihood of developing wet AMD 10 times that of individuals with the wild-type genotype.
All Author(s) ListDewan A, Liu MG, Hartman S, Zhang SSM, Liu DTL, Zhao C, Tam POS, Chan WM, Lam DSC, Snyder M, Barnstable C, Pang CP, Hoh J
Journal nameScience
Year2006
Month11
Day10
Volume Number314
Issue Number5801
PublisherAMER ASSOC ADVANCEMENT SCIENCE
Pages989 - 992
ISSN0036-8075
eISSN1095-9203
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesMultidisciplinary Sciences; MULTIDISCIPLINARY SCIENCES; Science & Technology - Other Topics

Last updated on 2021-11-05 at 01:14