Serum proteomic patterns for gastric lesions as revealed by SELDI mass spectrometry
Publication in refereed journal


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摘要SELDI mass spectrometry was used to investigate protein expression in sera of patients with gastric cancer and gastritis compared to normal volunteers. Differences in peak morphology and intensity were observed in regions of 5910 Da, 5084 Da, 6640 Da and 8691 Da. Patients with gastric cancer exhibited an up-regulation of the 5910 Da peak and a down-regulation of the 8691 Da peak compared to the healthy volunteers; there was also some bi-partitioning and tri-partitioning at the 5084 Da peak. When comparing the sera of these cancer patients with those of gastritis, the former had an up-regulation of the 5910 Da peak and a down-regulation of the 6640 Da peak. This is the first,report showing that SELDI sera analysis may be useful in the screening of gastric lesions. (c) 2006 Elsevier Inc. All rights reserved.
著者Liang Y, Fang MR, Li JC, Liu CB, Rudd JA, Kung HF, Yew DTW
期刊名稱Experimental and Molecular Pathology
出版年份2006
月份10
日期1
卷號81
期次2
出版社ACADEMIC PRESS INC ELSEVIER SCIENCE
頁次176 - 180
國際標準期刊號0014-4800
語言英式英語
關鍵詞biomarker; cancer; gastric adenocarcinoma; gastritis; SELDI
Web of Science 學科類別Pathology; PATHOLOGY

上次更新時間 2021-08-04 於 00:51