CD4(+) T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes
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AbstractEpstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes, presented by HLA alleles in Chinese people, the group at highest risk for NPC. We analyzed the CD4(+) T-cell responses to EBNA1 in 78 healthy Chinese donors and found marked focusing on a small number of epitopes in the EBNA1 C-terminal region, including a DP5-restricted epitope that was recognized by almost half of the donors tested and elicited responses able to recognize EBNA1-expressing, DP5-positive target cells.
All Author(s) ListTsang CW, Lin X, Gudgeon NH, Taylor GS, Jia H, Hui EP, Chan ATC, Lin CK, Rickinson AB
Journal nameJournal of Virology
Volume Number80
Issue Number16
Pages8263 - 8266
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesVirology; VIROLOGY

Last updated on 2020-16-10 at 00:44