Chronic hepatitis B viral infection independently predicts renal outcome in type 2 diabetic patients
Publication in refereed journal


摘要Aims/hypothesis: We examined the association between chronic hepatitis B virus (HBV) infection and clinical outcomes in a consecutive cohort of Chinese patients with type 2 diabetes. Subjects, materials and methods: Between 1995 and 1999, 2,838 type 2 diabetes patients underwent comprehensive assessments and blood screening for hepatitis B surface antigen ( HBsAg). The risk of occurrence of cardiovascular events and end-stage renal disease ( defined as need for dialysis, doubling of serum creatinine or serum creatinine >= 500 mu mol/l) was compared between HBsAg-positive and HBsAg-negative groups. Results: At baseline, HBV-infected patients (n=286, 10.1%) were younger (51.0 +/- 11.5 vs 53.7 +/- 12.7 years, p=0.004), had earlier onset of diabetes (51.0 +/- 11.5 vs 53.7 +/- 12.7 years, p=0.001) and a higher frequency of retinopathy ( 28 vs 22%, p=0.03) than non-HBV-infected patients. After a median follow-up of 3.5 years (interquartile range: 1.7-5.9 years) and adjustment of age, glycaemic control and other potential confounding factors, HBV-infected patients were more likely to develop end-stage renal disease than non-HBV infected patients (8.7 vs 6.4%) with a hazard ratio of 4.5 (95% CI 1.1-18.6). The difference in the frequency of cardiovascular endpoints was not statistically significant. Conclusions: In Chinese type 2 diabetes patients, chronic HBV infection was associated with increased risk of end-stage renal disease, and this was independent of other potential confounding factors. Early identification of HBV status and close surveillance of renal function are important in patients with type 2 diabetes who are living in areas where HBV is endemic or who are at risk of chronic HBV infection.
著者Cheng AYS, Kong APS, Wong VWS, So WY, Chan HLY, Ho CS, Lam CWK, Tam JS, Chow CC, Cockram CS, Chan JCN, Tong PCY
頁次1777 - 1784
關鍵詞Chinese; hepatitis B viral infection; renal outcome; type 2 diabetes
Web of Science 學科類別Endocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM

上次更新時間 2021-15-01 於 23:41