Aberrant expression of CC and CXC chemokines and their receptors in patients with asthma
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摘要This study further elucidates the roles of selected chemokines (IP-10, MIG, and RANTES) and their receptors (CCR3, CCR5, and CXCR3) in asthma. We compared their profiles in six groups of participants-atopic cohort and nonatopic cohort (each including controls and asthmatic patients with or without steroid therapy). Plasma concentration of IP-10 was significantly lower while that of RANTES and the expression of CCR3 were higher in asthmatic patients (all p < 0.05). Plasma RANTES correlated positively with the GINA severity score in all asthmatic patients (r=0.27, p < 0.05), and with IL-13 in nonatopic asthmatic patients (r=0.46, p < 0.05). In asthmatic patients, the ex vivo release of IP-10 and MIG was attenuated in PBMC activated with allergen, mitogens and IL-18 (p < 0.05). In conclusion, plasma RANTES may be a surrogate marker for asthma and the diminished Th1 related CXC chemokine production may contribute to Th2 predominance in asthma.
著者Lun SWM, Wong CK, Ko FWS, Ip WK, Hui DSC, Lam CWK
期刊名稱Journal of Clinical Immunology
出版年份2006
月份3
日期1
卷號26
期次2
出版社SPRINGER/PLENUM PUBLISHERS
頁次145 - 152
國際標準期刊號0271-9142
語言英式英語
關鍵詞asthma; chemokines; cytokines; peripheral blood mononuclear cells
Web of Science 學科類別Immunology; IMMUNOLOGY

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