Aberrant expression of CC and CXC chemokines and their receptors in patients with asthma
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AbstractThis study further elucidates the roles of selected chemokines (IP-10, MIG, and RANTES) and their receptors (CCR3, CCR5, and CXCR3) in asthma. We compared their profiles in six groups of participants-atopic cohort and nonatopic cohort (each including controls and asthmatic patients with or without steroid therapy). Plasma concentration of IP-10 was significantly lower while that of RANTES and the expression of CCR3 were higher in asthmatic patients (all p < 0.05). Plasma RANTES correlated positively with the GINA severity score in all asthmatic patients (r=0.27, p < 0.05), and with IL-13 in nonatopic asthmatic patients (r=0.46, p < 0.05). In asthmatic patients, the ex vivo release of IP-10 and MIG was attenuated in PBMC activated with allergen, mitogens and IL-18 (p < 0.05). In conclusion, plasma RANTES may be a surrogate marker for asthma and the diminished Th1 related CXC chemokine production may contribute to Th2 predominance in asthma.
All Author(s) ListLun SWM, Wong CK, Ko FWS, Ip WK, Hui DSC, Lam CWK
Journal nameJournal of Clinical Immunology
Year2006
Month3
Day1
Volume Number26
Issue Number2
PublisherSPRINGER/PLENUM PUBLISHERS
Pages145 - 152
ISSN0271-9142
LanguagesEnglish-United Kingdom
Keywordsasthma; chemokines; cytokines; peripheral blood mononuclear cells
Web of Science Subject CategoriesImmunology; IMMUNOLOGY

Last updated on 2020-03-06 at 00:39