Inhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus-mediated expression of human endostatin
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摘要Nasopharyngeal carcinoma (NPC) is a highly malignant and frequently metastasized tumor. Endostatin has been shown to inhibit NPC growth, but its efficacy against NPC metastasis has not been shown in vivo. Here, we established a NPC metastasis model in mice by transplanting EBV-positive NPC cells, C666-1, in the livers of nude mice and observed lung metastasis. Furthermore, we showed that tail vein injection of recombinant adenoassociated virus encoding human endostatin (rAAVh-Endo) significantly prolonged the median survival rate of NPC metastasis-bearing mice (from 22 to 37 days, P < 0.01). The rAAV-hEndo treatment resulted in a statistically significant reduction in tumor growth and microvessel formation. It also increased the apoptotic index in the primary liver tumor but not in the normal liver tissue. Importantly, no formation of liver or lung metastasis was detected. The potent inhibition of NPC metastasis suggests the feasibility of combining rAAV-hEndo gene therapy with other therapies for the prevention and treatment of NPC metastasis.
著者Li XP, Li CYS, Li XH, Ding YQ, Chan LLY, Yang PH, Li G, Liu X, Lin JS, Wang JD, He ML, Kung HF, Lin MC, Peng Y
期刊名稱Molecular Cancer Therapeutics
出版年份2006
月份5
日期1
卷號5
期次5
出版社AMER ASSOC CANCER RESEARCH
頁次1290 - 1298
國際標準期刊號1535-7163
電子國際標準期刊號1538-8514
語言英式英語
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-11-04 於 23:54