Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus
Publication in refereed journal


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摘要SARS-associated coronavirus was identified as the etiological agent of severe acute respiratory syndrome and a large virus pool was identified in wild animals. Virus generates drug resistance through fast mutagenesis and escapes antiviral treatment. siRNAs targeting different genes would be an alternative for overcoming drug resistance. Here, we report effective siRNAs targeting structural genes (i.e., spike, envelope, membrane, and nucleocapsid) and their antiviral kinetics. We also showed the synergistic effects of two siRNAs targeting different functional genes at a very low dose. Our findings may pave a way to develop cost effective siRNA agents for antiviral therapy in the future. (c) 2006 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
著者He ML, Zheng BJ, Chen Y, Wong KL, Huang JD, Lin MC, Peng Y, Yuen KY, Sung JJY, Kung HF
期刊名稱FEBS Letters
出版年份2006
月份5
日期1
卷號580
期次10
出版社ELSEVIER SCIENCE BV
頁次2414 - 2420
國際標準期刊號0014-5793
電子國際標準期刊號1873-3468
語言英式英語
關鍵詞inhibition of SCoV reproduction; RNA interference; SARS-associated coronavirus; siRNA; viral kinetics
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS; Cell Biology; CELL BIOLOGY

上次更新時間 2021-11-04 於 23:52