HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women
Publication in refereed journal


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摘要A population-based study was conducted on 256 southern Chinese with cervical intraepithelial neoplasia grade III (CIN 111) or invasive cervical cancer (ICC) and on 258 controls to examine the associations between HLA-B alleles, infection with high-risk human papillomaviruses (HPVs) and the development of cervical neoplasia. HLA-B15 was found to be protective for CIN III/ICC overall (p(corrected) = 0.003), and for HPV52-positive CIN III/ICC (p(corrected) = 0.003). A marginal protective effect of B15 was observed for HPV16-positive CIN III/ICC, but no significant associations were revealed for HPV18- or HPV58-positive cases. None of the HLA-B alleles were found to confer an increased risk for cervical neoplasia. HLA-B15 is common among Asian for whom HPV52, a worldwide uncommon HPV type, also exists in a relatively high prevalence. It would also be worthwhile to assess the association between HLA-B15, HPV52 and cervical cancer in other Asian populations. (c) 2005 Wiley-Liss, Inc.
著者Chan PKS, Cheung JLK, Cheung TH, Lin CK, Tam AOY, Chan DPC, Zhou DX, Lo KWK, Yim SF, Siu SSN
會議名稱22nd International Papillomavirus Conference
會議開始日01.05.2005
會議地點Vancouver
期刊名稱International Journal of Cancer
出版年份2006
月份3
日期15
卷號118
期次6
出版社WILEY-LISS
頁次1430 - 1435
國際標準期刊號0020-7136
電子國際標準期刊號1097-0215
語言英式英語
關鍵詞cervical cancer; Chinese; HLA; host genetics; HPV
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-21-02 於 00:03