Inhibitory effects of Selaginella tamariscina on immediate allergic reactions
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摘要The anti-allergic effects of a 70% ethanol extract from Selaginella tamariscina herb (EST) were evaluated in this study. EST given at the doses of 500 and 1000 mg/kg can inhibit mouse systemic anaphylactic shock induced by compound 48/80 in a dose-dependent manner. It can also dose-dependently block rat homologous passive cutaneous anaphylaxis and skin reactions caused by exogenous histamine and serotonin with a significant difference observed at the dose of 1000 mg/kg. In addition, EST can reduce histamine release from rat peritoneal mast cells triggered by compound 48/80 and an antigen in vitro. When incubated with rat mast cells, the extract (200 mu g/ml) can significantly elevate the intracellular cAMP levels. The finding suggests that EST inhibits mast cell-dependent, immediate allergic reactions. Its effects appear to be mediated by reducing the release of vasoactive amines such as histamine from mast cells via stabilizing the cell membrane and weakening the inflammatory action of these amines. Based on these results, Selaginella tamariscina and one of its active components flavonoids may be useful as potential remedies for allergic rhinitis and other allergy-related diseases.
著者Dai Y, But PPH, Chu LM, Chan YP
期刊名稱American Journal of Chinese Medicine
出版年份2005
月份1
日期1
卷號33
期次6
出版社WORLD SCIENTIFIC PUBL CO PTE LTD
頁次957 - 966
國際標準期刊號0192-415X
電子國際標準期刊號1793-6853
語言英式英語
關鍵詞anaphylactic shock; cAMP; histamine release; mast cells; passive cutaneous anaphylaxis; Selaginella tamariscina
Web of Science 學科類別General & Internal Medicine; Integrative & Complementary Medicine; INTEGRATIVE & COMPLEMENTARY MEDICINE; Medicine, General & Internal; MEDICINE, GENERAL & INTERNAL

上次更新時間 2021-11-05 於 01:10