The putative protein 6 of the severe acute respiratory syndrome-aassociated coronavirus: Expression and functional characterization
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要The SARS-CoV open reading frame 6 (ORF6) is transcribed into mRNA6 and encodes a putative 7.5 kDa accessory protein, SARS 6, with unknown function. In this study, we have confirmed the SARS 6 protein expression in lung and intestine tissues of the SARS patients and in SARS-CoV infected Vero E6 cells by immunohistochemistry. Further studies by immunoblot and confocal microscopy analyses revealed the expression and the endoplasmic reticulum (ER) localization of the recombinant SARS 6 protein in mammalian cells. Expression of SARS 6 protein in mammalian cells elicits biological activity of stimulating cellular DNA synthesis. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
著者Geng H, Liu YM, Chan WS, Lo AWI, Au DMY, Waye MMY, Ho YY
期刊名稱FEBS Letters
出版年份2005
月份12
日期19
卷號579
期次30
出版社ELSEVIER SCIENCE BV
頁次6763 - 6768
國際標準期刊號0014-5793
電子國際標準期刊號1873-3468
語言英式英語
關鍵詞coronavirus; ORF6; SARS 6 protein; SARS-CoV; severe acute respiratory syndrome
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS; Cell Biology; CELL BIOLOGY

上次更新時間 2020-11-09 於 01:00