Biases in human papillomavirus genotype prevalence assessment associated with commonly used consensus primers
Publication in refereed journal


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摘要Consensus primers targeting human papillomaviruses (HPVs) have biases in sensitivity toward certain HPV types. We applied 3 primer sets (GP5+/6+, MY09/11, PGMY09/11) in parallel on 120 Chinese cervical cancer specimens. GP5+/6+ exhibited a poor sensitivity for HPV52, for which the prevalence among squamous cell cervical cancer was underestimated from 14.6% to 0%. The fact that HPV52 should rank second in prevalence among squamous cell cervical carcinoma in Hong Kong could be missed if GP5+/6+, a worldwide commonly used primer set, was selected for HPV detection. Biases in HPV type-specific sensitivity may result in misprioritization of vaccine candidates. (c) 2005 Wiley-Liss, Inc.
著者Chan PKS, Cheung TH, Tam AOY, Lo KWK, Yim SF, Yu MMY, To KF, Wong YF, Cheung JLK, Chan DPC, Hui M, Margaret IP
期刊名稱International Journal of Cancer
出版年份2006
月份1
日期1
卷號118
期次1
出版社WILEY-LISS
頁次243 - 245
國際標準期刊號0020-7136
電子國際標準期刊號1097-0215
語言英式英語
關鍵詞chinese; detection; genotype; Hong Kong; human papillomavirus; PCR; vaccine
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-27-02 於 23:58