Biases in human papillomavirus genotype prevalence assessment associated with commonly used consensus primers
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AbstractConsensus primers targeting human papillomaviruses (HPVs) have biases in sensitivity toward certain HPV types. We applied 3 primer sets (GP5+/6+, MY09/11, PGMY09/11) in parallel on 120 Chinese cervical cancer specimens. GP5+/6+ exhibited a poor sensitivity for HPV52, for which the prevalence among squamous cell cervical cancer was underestimated from 14.6% to 0%. The fact that HPV52 should rank second in prevalence among squamous cell cervical carcinoma in Hong Kong could be missed if GP5+/6+, a worldwide commonly used primer set, was selected for HPV detection. Biases in HPV type-specific sensitivity may result in misprioritization of vaccine candidates. (c) 2005 Wiley-Liss, Inc.
All Author(s) ListChan PKS, Cheung TH, Tam AOY, Lo KWK, Yim SF, Yu MMY, To KF, Wong YF, Cheung JLK, Chan DPC, Hui M, Margaret IP
Journal nameInternational Journal of Cancer
Volume Number118
Issue Number1
Pages243 - 245
LanguagesEnglish-United Kingdom
Keywordschinese; detection; genotype; Hong Kong; human papillomavirus; PCR; vaccine
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-22-10 at 00:55