Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
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AbstractDanshen, the dried root of Salvia miltiorrhiza, has been widely used in China and, to a lesser extent, in Japan, the United States, and other European countries for the treatment of cardiovascular and cerebrovascular diseases. In China, the specific clinical use is angina pectoris, hyperlipidemia, and acute ischemic stroke. The current review covers its traditional uses, chemical constituents, phor macological activities, pharmacokinetics, clinical applications, and potential herb-drug interactions based on information obtained in both the English and Chinese literature. Although numerous clinical trials have demonstrated that certain Danshen products in China are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality Therefore, large randomized clinical trials and further scientific research to determine its mechanism of actions will be necessary to ensure the safety, effectiveness, and better understanding of its action.
All Author(s) ListZhou LM, Zuo Z, Chow MSS
Journal nameJournal of Clinical Pharmacology
Volume Number45
Issue Number12
Pages1345 - 1359
LanguagesEnglish-United Kingdom
KeywordsDanshen; danshensu; Salvia miltiorrhiza; salvianolic acid B; tanshinone IIA
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-30-03 at 00:15