Risk association between human leukocyte antigen - A allele and high-risk human papillomavirus infection for cervical neoplasia in Chinese women
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摘要To examine the association between human leukocyte antigen - A (HLA-A) allele polymorphism, human papillomavirus (HPV) infection, and risk for cervical neoplasia in Chinese women, 263 patients ( 155 with cervical intraepithelial neoplasia [CIN] II/III and 108 with invasive cervical cancer [ICC]) were compared with 572 controls. Overall, regardless of HPV status, a decreased risk for ICC was observed for patients with A*0207/ 0215N or A* 2402, and an increased risk was observed for patients with A* 1104. The protective association of A* 0207/0215N was reproduced in HPV-16-positive patients with ICC, but not in subgroups infected with other HPV types. The risk association between A* 1104 and both HPV-16 and HPV-18 was reproduced in the subgroups with CIN III/ICC. The protective association between A* 2402 and HPV-16, HPV- 18, HPV- 52, and HPV- 58 was consistently observed in all subgroups with CIN III/ICC, suggesting a linkage with a general antioncogenic genetic factor. The results of the present study indicate that HLA-A polymorphism is one of the host genetic factors that alter the risk for the development of cervical cancer in Chinese women.
著者Chan DPC, Cheung TH, Tam AOY, Cheung JLK, Yim SF, Lo KWK, Siu NSS, Zhou DX, Chan PKS
會議名稱22nd International Papilomavirus Conference
會議開始日30.04.2005
會議完結日06.05.2005
會議地點Vancouver
期刊名稱Journal of Infectious Diseases
出版年份2005
月份11
日期15
卷號192
期次10
出版社UNIV CHICAGO PRESS
頁次1749 - 1756
國際標準期刊號0022-1899
電子國際標準期刊號1537-6613
語言英式英語
Web of Science 學科類別Immunology; IMMUNOLOGY; Infectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY

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