Nuclear beta-catenin expression is rare and its potential association with short survival in colorectal signet-ring cell carcinoma
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摘要Colorectal signet-ring cell carcinoma (SRCC) is a rare cancer and the prognosis is usually very poor. The biologic pathways involved in its oncogenesis are unknown. beta-catenin, a key target in the Wnt-signaling pathway, is recognized to play an important role in the carcinogenesis in conventional colorectal carcinoma. This study explores the involvement of Wnt-signaling molecules beta-catenin and cyclin D1, cell cycle regulators cyclin D3, proliferative index Ki-67, apoptotic index, and angiogenic indicator CD31 in 20 colorectal SRCC paraffin-embedded specimens. Results showed that there were 2 specimens with nuclear beta-catenin and higher expression of cyclin D1 than the remaining 18 specimens. Surprisingly, those 2 patients had a much shorter survival of 6 months than the remaining 15 patients, who had around 24 months. Moreover, all colorectal SRCC specimens had an overexpression of cyclin D1, cyclin D3, and Ki-67, as well as much more angiogenesis and apoptosis than adjacent normal epithelial tissues. The authors make the preliminary comment that nuclear beta-catenin is a rare phenomenon in colorectal SRCC, but the involvement of it may indicate a worse prognosis with shorter survival than colorectal SRCC without nuclear beta-catenin expression. Besides, overexpression of cyclin D1, cyclin D3, Ki-67, and increased angiogenesis and apoptosis may play a vital role in promoting colorectal SRCC development.
著者Wong SCC, Chan ATC, Lo ESF, Lo YMD
期刊名稱APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
出版年份2005
月份9
日期1
卷號13
期次3
出版社LIPPINCOTT WILLIAMS & WILKINS
頁次248 - 251
國際標準期刊號1062-3345
語言英式英語
關鍵詞beta-catenin; colorectal; signet-ring cell carcinoma; Wnt signaling
Web of Science 學科類別Anatomy & Morphology; ANATOMY & MORPHOLOGY; Medical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY; Pathology; PATHOLOGY

上次更新時間 2020-26-11 於 01:35