Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus
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AbstractObjective. The costimulatory interactions of the B7 family molecules CD80 and CD86 on antigen-presenting cells with their T-cell counter-receptors CD28 and CTLA-4 modulate T lymphocyte-mediated immune responses in a reciprocal manner. We investigated the possible aberrant production of soluble (s) forms of the T-cell costimulatory molecules CD80, CD86, CD28 and CTLA-4 in plasma of patients with systemic lupus erythematosus (SLE), an autoimmune disease arising from T-lymphocyte dysregulation.
All Author(s) ListWong CK, Lit LCW, Tam LS, Li EK, Lam CWK
Journal nameRheumatology
Year2005
Month8
Day1
Volume Number44
Issue Number8
PublisherOXFORD UNIV PRESS
Pages989 - 994
ISSN1462-0324
eISSN1462-0332
LanguagesEnglish-United Kingdom
KeywordsCD28; CD80; CD86; CTLA-4; SLE
Web of Science Subject CategoriesRheumatology; RHEUMATOLOGY

Last updated on 2020-02-04 at 02:05