The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells
Publication in refereed journal


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摘要An outbreak of severe acute respiratory syndrome (SARS) occurred in China and the first case emerged in mid-November 2002. The aetiological agent of this disease was found to be a previously unknown coronavirus, SARS-associated coronavirus (SARS-CoV). The detailed pathology of SAIRS-CoV infection and the host response to the viral infection are still not known. The 3a gene encodes a non-structural viral protein, which is predicted to be a transmembrane protein. In this study, it was shown that the 3a protein was expressed in the lungs and intestinal tissues of SARS patients and that the protein localized to the endoplasmic reticulum in 3a-transfected monkey kidney Vero E6 cells. In vitro experiments of chromatin condensation and DNA fragmentation suggested that the 3a protein may trigger apoptosis. These data showed that overexpression of a single SARS-CoV protein can induce apoptosis in vitro.
著者Law PTW, Wong CH, Au TCC, Chuck CP, Kong SK, Chan PKS, To KF, Lo AWI, Chan JYW, Suen YK, Chan HYE, Fung KP, Waye MMY, Sung JJY, Lo YMD, Tsui SKW
期刊名稱Journal of General Virology
出版年份2005
月份7
日期1
卷號86
出版社SOC GENERAL MICROBIOLOGY
頁次1921 - 1930
國際標準期刊號0022-1317
電子國際標準期刊號1465-2099
語言英式英語
Web of Science 學科類別Biotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Virology; VIROLOGY

上次更新時間 2020-29-09 於 23:19