The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
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摘要Bananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC50 values in the range 0.5-3 mu M. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC50 of less than 10 mu M and a CC50 of over 300 mu M. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication.
著者Tanner JA, Zheng BJ, Zhou J, Watt RM, Jiang JQ, Wong KL, Lin YP, Lu LY, He ML, Kung HF, Kesel AJ, Huang JD
期刊名稱Cell Chemistry Biology
出版年份2005
月份3
日期1
卷號12
期次3
出版社CELL PRESS
頁次303 - 311
國際標準期刊號1074-5521
語言英式英語
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY

上次更新時間 2020-26-11 於 01:29